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ACTH
minimum sample volume required ~ 4ml
Test Code: ACT
Tube type: EDTA
Special instructions
Needs to be in the laboratory ASAP (must be frozen within 30 mins of collection).
All results must be interpreted in the context of the current cortisol levels, the time of sample collection and the clinical status of the patient.
Sent away
to Bristol Royal Infirmary
Reference range
5.0 - 50.0
Units
ng/L
Linked to
Cortisol
Turnaround Time
4
days
Department: Biochemistry
Clinical Application
ACTH (adrenocorticotropic hormone) is secreted by the anterior pituitary in response to corticotrophin-releasing hormone from the hypothalamus as well as in response to stress.
ACTH stimulates secretion of steroids including cortisol from the adrenal cortex.
ACTH is used in the investigation of Cushing's syndrome, and in differentiating primary from secondary causes of adrenal insufficiency. A sample for measurement of ACTH should be sent with the basal cortisol of a short synacthen test when this is performed in hospital, prior to commencing steroid cover. ACTH measurement will be undertaken if the short synacthen test is abnormal. Also useful in differentiation of cause of Cushing's syndrome (pituitary, adrenal or ectopic cause), but NOT in making the diagnosis of the syndrome itself (levels can be very low to very high depending on cause).
Webpage updated: June 2024
