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Lithium
(a.k.a Li)
minimum sample volume required ~ 5ml
Test Code: LIT
Tube type: SST
Special instructions
Measure lithium 12 hours post dose. Please see reports for interpretation and guidance.
NICE CG185 recommends measuring lithium every 3 months for the first year and every 6 months thereafter (or every 3 months for patients in certain groups).
Minimum retesting interval
Test should not be repeated within 1 day
Reference range
0.4 - 0.8
Units
mmol/L
Turnaround Time
1
day
Department: Biochemistry
Clinical Application
Careful monitoring of lithium is essential (including calcium, renal and thyroid function). NICE CG185 recommends measuring lithium every 3 months for the first year and every 6 months thereafter (or every 3 months for patients in certain groups).
NICE guidance is to try to maintain lithium concentrations below 0.8 mmol/L to reduce the risk of renal damage.
Typical treatment levels are often between 0.6 mmol/L – 0.8mmol/L, however this varies between patients and 0.4mmol/L may be sufficient. Higher levels can be needed during a relapse. Please refer to patient-specific guidelines from specialist team as appropriate.
If 12hr sample is 1.0 mmol/L or above please discuss with specialist team.
Please note: Phenylpropanol-amine and pseudoephedrine may cause falsely elevated results while Mefenorex may cause falsely low results.
Links:
» NICE guidance for bipolar disorder assessment and management
