Procollagen 3 peptide
(a.k.a P3NP)
minimum sample volume required ~ 5ml
Test Code: P3P
Tube type: SST
Special instructions
None
Clinical cut-off intervals
Indications for biopsy
Pre-treatment: >13.0
During treatment: >7.0 in at least 3 samples over 12 months
During treatment: >13.0 in 2 consecutive samples
Indications for withdrawal of methotrexate
During treatment: >17.0 in at least 3 samples over 12 months
Sent away
to the Metabolic Bone Laboratory, Norwich and Norfolk University Hospitals NHS Foundation Trust
Units
µg/L
Turnaround Time
28
days
Department: Biochemistry
Clinical Application
The decision to perform biopsy, withdraw treatment, or continue treatment despite raised PIIINP concentrations, must also take into account other factors, such as disease severity, patient age, and the ease with which alternative therapies may be used in place of methotrexate.