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Androstenedione
(a.k.a AND)
minimum sample volume required ~ 5ml
Test Code: AND
Tube type: SST
Other acceptable tube types
Lithium Heparin plasma
Special instructions
None
Sent away
to University Hospital of Wales, Cardiff
Reference range
Age and sex dependent reference ranges, please refer to report
Units
nmol/L
Linked to
DHEA-S
Turnaround Time
14
days
Department: Biochemistry
Clinical Application
Androstenedione (D4) is produced in the adrenal glands and gonads and is a precursor steroid for testosterone and oestrogens (oestrone and oestradiol).
Measurement may be indicated for -
1. Second line investigation of high testosterone in a woman.
2. Management of CAH due to 11ß- or 21-hydroxylase deficiency.
3. Diagnosis of 17ß-hydroxysteroid dehydrogenase deficiency.
Elevated androstenedione levels can cause symptoms or signs of hyperandrogenism in women. Men are usually asymptomatic, but through peripheral conversion can occasionally experience symptoms such as gynaecomastia.
Pronounced elevations of androstenedione may be indicative of androgen-producing adrenal or gonadal tumors.
Limitations: The combined oral contraceptive pill can reduce gonadotrophin-dependent androgen production.
Webpage updated: November 2024.
