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Metadrenaline (urine)
(a.k.a Metanephrine)
24 Hour Urine (acid Preservative)(Phone (82)4712 to order)
Test Code: MAD
Special instructions
Sample must be collected into a bottle already containing acid.
Adult reference ranges:
Male
Metadrenaline <2.21
Normetadrenaline <3.81
3-Methoxytyramine <2.81
Female
Metadrenaline <1.81
Normetadrenaline <3.01
3-Methoxytyramine <2.81
Sent away
to Freeman Hospital, Newcastle
Reference range
Paediatric ranges available on request.
Units
µmol/24 h
Turnaround Time
21
days
Department: Biochemistry
Clinical Application
Urine metanephrines may be performed for the investigation of suspected phaeochromocytoma, or paraganglioma (PPGL). A phaeochromocytoma is a rare neuroendocrine tumour which secretes excessive catecholamines. PPGLs may also secrete excess catecholamines when they arise in the sympathetic paravertebral ganglia of the abdomen, thorax and pelvis.
Substances which can interfere with analysis: Tricyclic antidepressants, α- and β-adrenergic receptor blockers, Calcium channel blockers, Stimulants (e.g. caffeine, nicotine), Levo(L)-dopa, Paracetamol, amongst others.
Patients should avoid caffeine for 24 hrs before, and during, collection. In addition the following drugs should be avoided for one week prior to the collection if clinically feasible: Phenothiazines, Tricyclic antidepressants including imipramine, labetalol, sotalol and monoamine oxidase inhibitors (MAOIs) and Chlorpromazine, and paracetamol.
Webpage updated: September 2024.
Links:
» Patient Instructions for METS Acidified 24 Hour Urine Collection
