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Dihydropyrimidine Dehydrogenase
(a.k.a DPD-5FU toxicity, DPD-DNA)
minimum sample volume required ~ 4ml

Test Code: DPD

Special instructions
None

Interpretation
DPYD genotype will be determined and possible fluoropyrimidine toxicity predicted.



Sent away to Genetics department, Southmead Hospital, Bristol

Turnaround Time
21 days

Department: Biochemistry

Clinical Application
Dihydropyrimidine dehydrogenase (DPD) is the enzyme involved in the metabolism of uracil and thymine. Deficiency of this enzyme can lead to the life threatening toxicity following exposure to the chemotherapy drug 5-fluorouracil and Tegafur-uracil.