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11-deoxycortisol
minimum sample volume required ~ 5ml
Test Code: 11C
Tube type: SST
Other acceptable tube types
EDTA
Special instructions
Collect sample at 9am.
In neonates, the sample should be taken at least 48 hours post birth.
Please note: the reference range quoted applies to adults only. No specific paediatric reference range is quoted, however each result will have interpretative comments.
Sent away
to King's College Hospital, London
Contact Laboratory before requesting
Reference range
0.7 - 2.7
Units
nmol/L
Turnaround Time
14
days
Department: Biochemistry
Clinical Application
Useful in diagnosis of 11ß-hydroxylase deficiency (high levels).
11-Deoxycortisol may be indicated in the diagnosis and monitoring of congenital adrenal hypoplasia (CAH) due to 11ß-hydroxylase deficiency. This is an autosomal recessive disorder causing about 5-8% of cases of CAH and resulting in androgen excess, virilisation and hypertension. The majority of CAH cases are due to 21-hydroxylase deficiency which results in an increase in 17-hydroxyprogesterone. 11-Deoxycortisol may be requested when CAH is suspected on clinical grounds and serum 17-OH progesterone levels are equivocal.
11-Deoxycortisol may also be used in assessing adrenal response in the metyrapone test. Metyrapone is an inhibitor of 11ß-hydroxylase activity. In the differential diagnosis of Cushing’s syndrome, metyrapone is given and subsequent changes in serum concentrations of 11-deoxycortisol provide strong (but not absolute) indicators of the site of the primary lesion.
Webpage updated: June 2024
